LncRNA LINC00342 contributes to the growth and metastasis of colorectal cancer via targeting miR-19a-3p/NPEPL1 axis

Abstract Background Long intergenic non-protein coding RNA 00342 (LINC00342) has been identified as a novel oncogene. However, the functional role of LINC00342 in colorectal cancer (CRC) remains unclear. Methods The expression is detected by real-time PCR (RT-PCR) analysis. Cell proliferation, migration and invasion xenograft model are examined to analyze biological functions vitro vivo using colony formation, would healing transwell analyses. Dual-luciferase reporter immunoprecipitation (RIP) assays used identify target interactions between LINC00342, miR-19a-3p aminopeptidase like 1 (NPEPL1). Results was highly expressed CRC. Down-regulation inhibited cell proliferation metastasis CRC cells. Moreover, knocking down tumor growth vivo. Mechanistic investigation revealed that might sponge regulate NPEPL1 expression. Further indicated ontogenesis facilitated due depletion NPEPL1. Conclusion promotes progression competitively binding with